A man with depression, for last en years, has taken medication from all over the country including SSRI, tricyclics, anti psychotics and benzodiazepines. Occasionally felt partial improvement but never able to work satisfactorily and never able to satisfy his domestic life despite having a desire to do so. Depression improved with venlaxafine and mirtazipine combined while a combination of selenium, carnitine ad CALADIUM treated his psychogenic impotence completely. One month later he was completely well , a feeling which he has never felt in last ten years.